Sodium Thiosulfate → 1-{2-(2,4-difluorophenyl)-3,3-difluoro-2-methoxy-3-[(2-methoxyethyl)sulfonyl]propyl}-1H-1,2,4-triazole

Participants

Reaction Steps

To a solution of 1-{2-(2,4-difluorophenyl)-3,3-difluoro-2-methoxy-3-[(2-methoxyethyl)thio]propyl}-1H-1,2,4-triazole (800 mg, 2.12 mmol) in dichloromethane (10 ml), 85% m-chloroperbenzoic acid (1.25 g, 5.09 mmol) was added at room temperature, followed by stirring at room temperature for 3 hours. After the completion of the reaction, a saturated aqueous solution of sodium thiosulfate and a saturated aqueous solution of sodium bicarbonate were added to the reaction mixture and the resulting mixture was stirred. The dichloromethane solution was separated, washed with water, dried over magnesium sulfate and distilled off under reduced pressure. The residue so obtained was subjected to a silica gel column. From the chloroform elute fraction, 700 mg (yield: 81%) of 1-{2-(2,4-difluorophenyl)-3,3-difluoro-2-methoxy-3-[(2-methoxyethyl)sulfonyl]propyl}-1H-1,2,4-triazole were obtained as a yellow oil.

Provenance & Evidence