HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyphenol → 1-(3-Methoxyphenoxy)-4,4-dimethyl-2-pentanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-bromo-4,4-dimethylpentan-2-one | HCID 222585 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-Methoxyphenoxy)-4,4-dimethyl-2-pentanone | HCID 22459019 | — |
Reaction Steps
A stirred solution of the product from Step B (1.626 grams) in dry DMF (18 mL) was combined with 3-methoxyphenol (1.256 grams) and cesium carbonate (3.292 grams). The mixture was stirred for 2.5 hours. The reaction was partitioned between isopropyl acetate and pH4 pthalate buffer. The organic was washed twice with water, dried over magnesium sulfate and filtered. Concentration furnished an oil from which the title compound was isolated by chromatography over silica gel (4:1 hex/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008237 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-6ef3253ee57342a08b5f9df8295e6386 |
| Source note | uspto-grants-1999_12 |