反应详情

温度

150 °C

Isoprene (350 g, 5.1 mol) and dimethyl maleate (741 g, 5.1 mol) were loaded into a stainless steel autoclave. The autoclave was sealed and heated to 150° C. The temperature of the autoclave increased to 195° C. due to the heat of the reaction. The temperature was held at 160° C. for 1 hour. Gas chromatography (GC) analysis indicated the completion of the reaction. The autoclave was then cooled to room temperature. Simple distillation of the resulting mixture provided 4-methyl-cyclohex-4-ene-1,2-dicarboxylic acid dimethyl ester (725 g, 3.4 mol, 66% yield) as a light yellow liquid.

1. customThe autoclave was sealed
2. temperatureThe temperature of the autoclave increased to 195° C. due to the
3. temperatureheat of the reaction
4. customthe completion of the reaction
5. temperatureThe autoclave was then cooled to room temperature
6. distillationSimple distillation of the resulting mixture