Boron tribromide → HCID 22459036, compound

Participants

Reaction Steps

A stirred, -10° C. solution of the product from Step B (2.066 grams; dry methylene chloride; 20 mL) was treated with 1M boron tribromide solution (methylene chloride; 8.40 mL). After 15 minutes, the reaction was warmed to ambient temperature and stirred another 15 minutes. It was partitioned between isopropyl acetate and pH7 phosphate buffer, then washed twice more with pH7 buffer and dried over magnesium sulfate. Filtration and evaporation produced an oil which was chromatographed over silica gel (step gradient; CH2Cl2 to 40:1 CH2Cl2 /ethyl acetate). The title compound was isolated as a pale yellow solid.

Provenance & Evidence