Sodium borohydride → 6-Benzyloxy-2,2-dimethylchroman-4-ol

Participants

Reaction Steps

A solution of 20.0 g (71 mmol) of 6-benzyloxy-2,2-dimethylchroman-4-one and 2.94 g (78 mmol) of sodium borohydride in 100 ml of methanol and 300 ml of ethanol was stirred at RT for 3 h. The reaction mixture was then poured into 1300 ml of ice-water, and the precipitate was filtered off with suction and dried under reduced pressure. This procedure gave 19.3 g of 6-benzyloxy-2,2-dimethylchroman-4-ol, m.p. 83-84° C.

Provenance & Evidence