HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 6-Benzyloxy-2,2-dimethyl-3,4-epoxychroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 6-Benzyloxy-3-bromo-2,2-dimethyl-chroman-4-ol | HCID 19593332 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Benzyloxy-2,2-dimethyl-3,4-epoxychroman | HCID 10924007 | 103.2% |
Reaction Steps
A solution of 9.5 g (28.5 mmol) of 6-benzyloxy-3-bromo-2,2-dimethyl-chroman-4-ol in 100 ml of THF was stirred overnight with 4.6 g (82 mmol) of potassium hydroxide powder. The batch was subsequently filtered through Celite and the filtrate was concentrated using a rotary evaporator, giving 8.3 g of 6-benzyloxy-2,2-dimethyl-3,4-epoxychroman, m.p. 70-72° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008245 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-abff71dbd7f342b5984830f7423c0340 |
| Source note | uspto-grants-1999_12 |