1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 9797986, compound

Participants

Reaction Steps

A solution of 0.5 g (1.3 mmol) of N-(6-butoxy-3-acetoxy-2,2-dimethylchroman-4-yl)-N-methyl-methanesulfonamide (Example 6) and 1.1 g (7.5 mmol) of DBU in 2.5 ml of toluene was heated at 105° C. for 60 h. The reaction mixture was diluted with EA and washed with hydrochloric acid until the aqueous phase gave an acidic reaction. The mixture was washed with sodium bicarbonate solution, dried over magnesium sulfate and concentrated i. vac., giving 0.3 9 of N-(6-butoxy-2,2-dimethyl-2H-chromen-4-yl)-N-methyl-methanesulfonamide; m.p. 114-116° C.

Provenance & Evidence