1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 9886858, compound

Participants

Reaction Steps

A solution of 3.5 g of (±)-trans-N-[3-acetoxy-6-(4,4,4-trifluorobutoxy)-2,2-dimethylchroman-4-yl]-N-methyl-methanesulfonamide (example 21) and 6.8 g of DBU in 30 ml of toluene was heated at 105° C. for 20 h. The reaction mixture was diluted with EA and washed with hydrochloric acid until the aqueous phase gave an acidic reaction. The mixture was washed with sodium bicarbonate solution, dried over magnesium sulfate, concentrated i. vac. and triturated with heptane, giving 1.7 g N-[6-(4,4,4-trifluorobutoxy)-2,2-dimethyl-2H-chromen-4-yl]-N-methyl-methanesulfonamide; m.p. 118° C.

Provenance & Evidence