Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | HCID 19592542 | HCID 19592542 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 19592526 | HCID 19592526 | 90.9% |
Reaction Steps
A mixture of 4-[bis(ethoxycarbonyl)methyl]-3-bromo-8-nitroquinoline (316 mg), lithium chloride (65.1 mg), water (13.8 mg) in dimethyl sulfoxide was stirred for 20 minutes at 130° C. The mixture was partitioned between ethyl acetate and water, and the organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo to give 3-bromo-4-ethoxycarbonylmethyl-8-nitroquinoline (236.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06008230 |
|---|
| Source dataset | uspto-grants-1999_12 |
|---|
| ORD ID | ord-eaea2e2ab3f643b5a7fe9716c4ba2f53 |
|---|
| Source note | uspto-grants-1999_12 |
|---|
