Tributylvinyltin → HCID 19592870, compound

Participants

Reaction Steps

A mixture of 8-nitro-4-(trifluoromethanesulfonyloxy)quinoline (6.0 g), tri-n-butyl(vinyl)tin (6.49 g), tetrakis(triphenylphosphine)palladium(0) (1.08 g) and lithium chloride (2.37 g) in dioxane (120 ml) was refluxed for 1.5 hours. The mixture was concentrated in vacuo, and ethyl acetate (200 ml) was added to the residue. The mixture was stirred for 1 hour, and insoluble material was filtered off. The residue was purified by flash chromatography (ethyl acetate-n-hexane) to give 8-nitro-4-vinylquinoline (2.39 g).

Provenance & Evidence