HuagongsheHuagongshe Chemistry Print Report · For research reference only
Quinoline, 3-bromo-8-nitro- → HCID 19592322, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Quinoline, 3-bromo-8-nitro- | HCID 79286 | — |
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 19592322 | HCID 19592322 | 53.5% |
Reaction Steps
A mixture of 8-nitro-3-bromoquinoline (300 mg), tri-n-butyl(vinyl)tin (491 mg) and tetrakis(triphenylphosphine)palladium(0) (28 mg) in dimethoxyethane (6 ml) was refluxed for 1 hour. The mixture was concentrated in vacuo, and the residue was purified by column chromatography on silica gel (n-hexane-toluene) to give 8-nitro-3-vinylquinoline (127 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008230 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-c367bb19d7b34f08ab462956dee6c590 |
| Source note | uspto-grants-1999_12 |