Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-Dichlorobenzoyl chloride | HCID 78392 | — |
| Reactant | 8-Amino-4-quinolinyl 2,6-dichlorobenzoate | HCID 19592446 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 19592677 | HCID 19592677 | 90.9% |
Reaction Steps
A mixture of 8-amino-4-(2,6-dichlorobenzoyloxy)quinoline (210 mg), 2,6-dichlorobenzoyl chloride (145 mg) and triethylamine (191 mg) in ethylene chloride (3 ml) was stirred for 24 hours at 70° C. The mixture was diluted with dichloromethane, washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was washed with diethyl ether to give 4-(2,6-dichlorobenzoyloxy)-8-(2,6-dichlorobenzoylamino)quinoline (290 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06008230 |
|---|
| Source dataset | uspto-grants-1999_12 |
|---|
| ORD ID | ord-91068dc9675f42c8bed51b89d9363791 |
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| Source note | uspto-grants-1999_12 |
|---|
