Tetrabutylammonium Fluoride → HCID 19593035, compound

Participants

Reaction Steps

To a solution of 8-(2,6-dichlorobenzoylamino)-3-(trimethylsilylethynyl)quinoline (150 mg) in tetrahydrofuran (3 ml) was added 1M solution of tetrabutylammonium fluoride in tetrahydrofuran (0.04 ml) under ice-cooling, and the mixture was stirred for 2 hours at the same temperature. The mixture was diluted with dichloromethane, washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate:n-hexane, 1:4, v/v) to give 8-(2,6-dichlorobenzoylamino)-3-ethynylquinoline (111 mg).

Provenance & Evidence