HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 613482Generated: October 29, 2026
Water → 8-(2,6-Dichlorobenzoylamino)-4-(2-methoxyethylamino)quinoline
https://huagongshe.com/reaction/613482
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 4-Chloro-8-(2,6-dichlorobenzoylamino)quinoline | HCID 19592564 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 8-(2,6-Dichlorobenzoylamino)-4-(2-methoxyethylamino)quinoline | HCID 19592510 | 58.6% |
Reaction Steps
A mixture of 4-chloro-8-(2,6-dichlorobenzoylamino)quinoline (100 mg) and 2-methoxyethylamine (314 mg) in N-methylpyrrolidone (1 ml) was heated at 120° C. overnight. Water (3 ml) was added thereto under ice-cooling, and the mixture was stirred for 1 hour. The resulting precipitate was collected by filtration, and the residue was purified by preparative thin layer chromatography (methanoldichloromethane) to give 8-(2,6-dichlorobenzoylamino)-4-(2-methoxyethylamino)quinoline (65 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06008230 |
|---|
| Source dataset | uspto-grants-1999_12 |
|---|
| ORD ID | ord-dc6e75d722ca4b0c8756d753ca37e306 |
|---|
| Source note | uspto-grants-1999_12 |
|---|
