HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → 3-Bromomethyl-8-(2,6-dichlorobenzoylamino)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 8-(2,6-Dichlorobenzoylamino)-3-hydroxymethylquinoline | HCID 19592295 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Bromomethyl-8-(2,6-dichlorobenzoylamino)quinoline | HCID 19592388 | 71.5% |
Reaction Steps
To a solution of 8-(2,6-dichlorobenzoylamino)-3-hydroxymethylquinoline (300 mg) in tetrahydrofuran were added carbon tetrabromide (573 mg) and triphenylphosphine (453 mg), and the mixture was stirred for 30 minutes at ambient temperature. Insoluble material was filtered off, and the filtrate was evaporated in vacuo. The residue was purified by column chromatography on silica gel (dichloromethane) to give 3-bromomethyl-8-(2,6-dichlorobenzoylamino)quinoline (253.4 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008230 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-2c27eaad265041d6a1f136f7533522fc |
| Source note | uspto-grants-1999_12 |