Water → HCID 19592460, compound

Participants

Reaction Steps

To a solution of 3-acetyl-8-(2,6-dichlorobenzoylamino)-4-methoxyquinoline (115 mg) in tetrahydrofuran was added sodium borohydride (16.8 mg) at 0° C., and the mixture was stirred for 30 minutes at the same temperature. The mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo to give 8-(2,6-dichlorobenzoylamino)-3-(1-hydroxyethyl)-4-methoxyquinoline (85.1 mg).

Provenance & Evidence