Sodium Hydroxide → HCID 19592965, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8-(2,6-dichlorobenzoylamino)-3-ethoxycarbonylquinoline (300 mg), 1N sodium hydroxide solution (1.95 ml) in tetrahydrofuran (10 ml) was stirred for 6 hours at 50° C. The mixture was concentrated in vacuo, and water was added to the residue. The solution was washed with diethyl ether, and the aqueous layer was adjusted to pH 3 with 1N hydrochloric acid. The resulting precipitate was collected by filtration and washed with water to give 3-carboxy-8-(2,6-dichlorobenzoylamino)quinoline (251.1 mg).

Provenance & Evidence