Ammonium Chloride → HCID 19592360, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-(2,6-dichlorobenzoylamino)-4-ethoxy-3-ethoxycarbonylquinoline (179 mg) in tetrahydrofuran was added lithium borohydride (22.5 mg), and the mixture was stirred for 4 hours at 50° C. To the mixture was dropwise added saturated ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate solution and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate-n-hexane) to give 8-(2,6-dichlorobenzoylamino)-4-ethoxy-3-hydroxymethylquinoline (55.9 mg).

Provenance & Evidence