Thionyl Chloride → HCID 19592582, compound

Participants

Reaction Steps

To a solution of 3-carbamoyl-8-(2,6-dichlorobenzoylamino)-4-ethoxyquinoline (122 mg) in dimethylformamide was added thionyl chloride (53.9 mg), and the mixture was stirred for 30 minutes at ambient temperature. The mixture was poured into saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate-n-hexane) to give 3-cyano-8-(2,6-dichlorobenzoylamino)-4-ethoxyquinoline (89.9 mg).

Provenance & Evidence