Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | HCID 19592415 | HCID 19592415 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 19592346 | HCID 19592346 | 75.3% |
Reaction Steps
A mixture of 4-bromomethyl-8-(2,6-dichlorobenzoylamino)-3-ethoxycarbonylquinoline (150 mg) and imidazole (106 mg) in dimethoxyethane was stirred for 1 hour at 70° C. The mixture was evaporated in vacuo, and the residue was purified by preparative thin layer chromatography (methanoldichloromethane) to give 8-(2,6-dichlorobenzoylamino)-3-ethoxycarbonyl-4-(imidazol-1-ylmethyl)quinoline (110 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06008230 |
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| Source dataset | uspto-grants-1999_12 |
|---|
| ORD ID | ord-1ac699ed73d04a89ad5eaf0f5d8f810c |
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| Source note | uspto-grants-1999_12 |
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