2-Methoxyethylamine → HCID 19592849, compound

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Reaction Steps

A mixture of 4-bromomethyl-8-(2,6-dichlorobenzoylamino)-3-ethoxycarbonylquinoline (100 mg), 2-methoxyethylamine (18.7 mg) and N,N-diisopropyl-N-ethylamine (134 mg) in ethylene chloride (1 ml) was stirred for 2 hours at ambient temperature. The mixture was diluted with dichloromethane, washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by preparative thin layer chromatography (methanoldichloromethane) to give 6-(2,6-dichlorobenzoylamino)-2,3-dihydro-2-(2-methoxyethyl)-1H-pyrrolo-[3,4-c]quinolin-3-one (76 mg).

Provenance & Evidence