Sodium Hydroxide → HCID 19592883, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-ethoxycarbonylmethyl-8-(2,6-dichlorobenzoylamino)quinoline (1.03 g) in ethanol (6 ml) was added 1N-aqueous sodium hydroxide solution (3.83 ml), and the mixture was stirred at 50° C. for two hours. The organic solvent was removed in vacuo and the aqueous residue was neutralized with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried and evaporated. The residue was crystallized spontaneously and it was triturated with ethyl acetate to give 4-carboxymethyl-8-(2,6-dichlorobenzoylamino)quinoline (703 mg).

Provenance & Evidence