Water → HCID 19592820, compound

Participants

Reaction Steps

A suspension of 3-chloromethyl-1,4-dihydro-8-nitro-4-oxoquinoline (2.0 g) in water (30 ml) was refluxed for 15 minutes and allowed to stand to ambient temperature. The resulting precipitates were collected by filtration and washed with water to give 1,4-dihydro-3-hydroxymethyl-8-nitro-4-oxoquinoline (1.82 g). mpD 182-184° C. NMR (DMSO-d6, δ): 4.41 (2H, s), 5.14 (1H, br), 7.49 (1H, t, J=7 Hz), 8.00 (1H, s), 8.59 (1H, d, J=7 Hz), 8.66 (1H, d, J=7 Hz)

Provenance & Evidence