Triphenylphosphine → HCID 19592729, compound

Participants

Reaction Steps

To a solution of 8-(2,6-dichlorobenzoylamino)-3-ethyl-4-(2-hydroxyethyl)quinoline (405 mg) in dichloromethane were added N-bromosuccinimide (241 mg) and triphenylphosphine (355 mg) under water cooling, and the mixture was stirred for 30 minutes at the same temperature. The mixture was concentrated in vacuo, and the residue was purified by column chromatography on silica gel (dichloromethane) and crystallized from n-hexane to give 4-(2-bromoethyl)-8-(2,6-dichlorobenzoylamino)-3-ethylquinoline (424 mg).

Provenance & Evidence