Hydrochloric Acid → HCID 19592334, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,4-dihydro-8-nitro-4-oxoquinoline (10 g) and 1,3,5-trioxane (23.7 g) in dioxane (100 ml) and conc. hydrochloric acid (200 ml) was stirred for 3.5 hours at 90° C. and allowed to stand to ambient temperature. To the mixture was added ice water (700 g), and the mixture was stirred for 1 hour. The resulting precipitates were collected by filtration and washed with cold water to give 3-chloromethyl-1,4-dihydro-8-nitro-4-oxoquinoline (6.5 g).

Provenance & Evidence