Acetic Anhydride → HCID 19592733, compound

Participants

Reaction Steps

To a suspension of 3-amino-6-(2,6-dichlorobenzoylamino)-1H-pyrazolo[4,3-c]quinoline (200 mg) in 1,2-dichloroethane (2 ml) was added acetic anhydride (302 mg), and the reaction mixture was refluxed for 12 hours. The solution was allowed to cool to ambient temperature and the solvent was evaporated in vacuo. The residue was triturated with water-ethanol, and the precipitate was collected. The crude product was purified by column chromatography on silica gel (ethyl acetate-n-hexane) to give 2-acetyl-6-(2,6-dichlorobenzoylamino)-2,3-dihydro-3-imino-1H-pyrazolo[4,3-c]-quinoline as a yellow crystal (60 mg) and 3-acetamido-6-(2,6-dichlorobenzoylamino)-1H-pyrazolo[4,3-c]quinoline as a white crystal (30 mg). 2-Acetyl-6-(2,6-dichlorobenzoylamino)-2,3-dihydro-3-imino-1H-pyrazolo[4,3-cilquinoline

Provenance & Evidence