HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 8-(2,6-Dichlorobenzoylamino)-4-(2,5-dioxopyrrolidin-1-ylamino)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 19592904 | HCID 19592904 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-(2,6-Dichlorobenzoylamino)-4-(2,5-dioxopyrrolidin-1-ylamino)quinoline | HCID 19592812 | 54.4% |
Reaction Steps
To a solution of 8-(2,6-dichlorobenzoylamino)-4-[2-(3-carboxypropanoyl)hydrazino]quinoline (138 mg) in dimethylformamide (3 ml) were added 1-hydroxybenzotriazole (45.9 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (65.1 mg) at ambient temperature, and the mixture was stirred at the same temperature overnight. To the mixture was added water, and the resulting precipitates were collected by filtration to give 8-(2,6-dichlorobenzoylamino)-4-(2,5-dioxopyrrolidin-1-ylamino)quinoline (72 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008230 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-c5f2a3e94c0f49d0b3b3cd5edaddeb81 |
| Source note | uspto-grants-1999_12 |