N-methyl-2-pyrrolidone → HCID 19592796, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-8-(2,6-dichlorobenzoylamino)-6-methylquinoline (562 mg) in N-methylpyrrolidone (6 ml) was added hydrazine hydrate, and the mixture was heated at 90° C. for 6 hours. The mixture was diluted with ethyl acetate, washed with water and brine, dried over magnesium sulfate and concentrated. The residue was dissolved in methylene chloride and acetone and then concentrated. The residual solid was treated with hot ethanol (5 ml), allowed to cool to ambient temperature, filtered and washed with ethanol to give 8-(2,6-dichlorobenzoylamino)-6-methyl-4-(2-isopropylidenehydrazino)quinoline (560 mg) as an off-white crystal.

Provenance & Evidence