Potassium Carbonate → HCID 53933818, compound

Participants

Reaction Steps

To a suspension of 8-(2,6-dichlorobenzoylamino)-1,4-dihydro-3-methyl-4-oxoquinoline (130 mg), potassium carbonate (155 mg) and N-methylpyrrolidone (3 ml) was added cinnamyl bromide (81.2 mg), and the mixture was stirred for 2.5 hours at ambient temperature. The mixture was extracted with ethyl acetate, and the extract was washed with water and brine, dried over magnesium sulfate and concentrated in vacuo. The residue was crystallized from ethanol to give 4-cinnamyloxy-8-(2,6-dichlorobenzoylamino)-3-methylquinoline (125 mg) as white crystal.

Provenance & Evidence