HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 613576Generated: October 29, 2026
Hydrochloric Acid → 4-Amino-8-(2,6-dichlorobenzoylamino)quinoline
https://huagongshe.com/reaction/613576
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 8-(2,6-Dichlorobenzoylamino)-4-[(triphenylphosphoranylidene)amino]quinoline | HCID 19592979 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Amino-8-(2,6-dichlorobenzoylamino)quinoline | HCID 19592524 | 100.1% |
Reaction Steps
A mixture of 8-(2,6-dichlorobenzoylamino)-4-[(triphenylphosphoranylidene)amino]quinoline (310 mg), 6N hydrochloric acid (5 ml) and acetic acid (5 ml) was heated for 3 hours at 130° C. After cooling, the mixture was neutralized with 6N sodium hydroxide solution, and the insoluble material was collected by filtration. The residue was recrystallized from ethyl acetate to give 4-amino-8-(2,6-dichlorobenzoylamino)quinoline (174 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06008230 |
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| Source dataset | uspto-grants-1999_12 |
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| ORD ID | ord-d2585a3889fd4f3a9d430e42359e0a3e |
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| Source note | uspto-grants-1999_12 |
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