HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 19592861, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 3-(Methoxycarbonyl)benzoic acid | HCID 601880 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 86754991 | HCID 86754991 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19592861 | HCID 19592861 | 91.8% |
Reaction Steps
A mixture of 8-amiino-3-bromoquinoline (330 mg), 3-methoxycarbonylbenzoic acid (267 mg), l-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (369 mg) and 1-hydroxybenzotriazole (300 mg) in dimethylformamide (5 ml) was stirred at ambient temperature overnight. To the mixture was added water, and the resulting precipitates were collected by filtration, washed with hot methanol and dried to give 3-bromo-8-[3-(methoxycarbonyl)benzoylamino]quinoline (390 mg) as pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008230 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-a455fec9d6634f4ab508f4e144778791 |
| Source note | uspto-grants-1999_12 |