Sodium Iodide → HCID 19592750, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-(2,6-dichlorobenzoylamino)-1,4-dihydro-3-methoxymethyl-4-oxoquinoline (209 mg) in N-methylpyrrolidone (4 ml) were added 3-chloromethylpyridine hydrochloride (109 mg), potassium carbonate (153 mg) and sodium iodide (20 mg), and the mixture was stirred for 4 hours at 80° C. The mixture was partitioned between ethyl acetate and water, and the separated organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was crystallized from ethanol to give 8-(2,6-dichlorobenzoylamino)-3-methoxymethyl-4-(pyridin-3-ylmethoxy)quinoline (170 mg) as white crystal.

Provenance & Evidence