HRID613695

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(CCc1ccccc1)N[C@H]1CCC(=O)N2CCC[C@@H](C(=O)O)N2C1=O

HCID22881931

未命名化合物

结构：CC(C)(C)OC(=O)[C@@H]1CCCN2CCC[C@H](NC(=O)CCc3ccccc3)C(=O)N12

HCID57148912

未命名化合物

PRODUCTS

生成物

结构：O=C(CCc1ccccc1)N[C@H]1CCCN2CCC[C@@H](C(=O)O)N2C1=O

HCID22881932

未命名化合物

收率 96%

PROCEDURE

实验过程

was prepared from (1S,9S)t-butyl octahydro-10-oxo-9-(3-phenylpropionylamino)-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylate (44b) by the method described for compound 45a to afford 657 mg (96%) of 45b as a crystalline solid: mp. 198-202° C.; [α]D23 -86.2° (c 0.5, CH3OH); IR (KBr) 3294, 2939, 1729, 1645, 1620, 1574, 1453, 1214; 1H NMR (CD3OD) δ 7.92 (1H, d, J=7.9), 7.20 (5H, m), 5.29 (1H, m), 4.90 (1H, m), 3.47 (1H, m), 3.08 (2H, m), 2.90 (2H, m), 2.55 (3H, m), 2.36 (1H, m), 1.81 (5H, m), 1.43 (2H, m). MS(FAB, m/z) 360 (M+ +1), 211,143,91.