HRID613717

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N1C[C@H](NC(=O)c2ccccc2)C(=O)N(CC(=O)O)c2ccccc21

HCID18396555

未命名化合物

结构：CC(=O)N1C[C@H](NC(=O)c2ccccc2)C(=O)N(CC(=O)OCc2ccccc2)c2ccccc21

HCID57124097

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CN1C(=O)[C@@H](NC(=O)c2ccccc2)CN(C(=O)CCc2ccccc2)c2ccccc21

HCID57159598

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Method B. (3S)2-Oxo-3-benzoylamino-5-acetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid (603d). A mixture of (3S)-2-oxo-3-(benzoylamino)-5-acetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid benzyl ester (602d; 510 mg, 1.08 mmol) and 5% Pd/C (250 mg) in MeOH (10 ml) stirred under H2 (1 atm) for 0.5 h. The reaction was filtered and concentrated in vacuo 410 mg of 603d as a white solid.

WORKUP

后处理

filtrationThe reaction was filtered
concentrationconcentrated in vacuo 410 mg of 603d as a white solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-393528d6890540caa54c3ef93bf88ac7
来源数据集: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06008217
来源说明: uspto-grants-1999_12

反应 SMILES

O=C1N(CC(O)=O)C2C=CC=CC=2N(C(=O)C)C[C@@H]1N[C:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[CH2:29]([O:36][C:37](=[O:63])[CH2:38][N:39]1[C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=2[N:43]([C:50](=[O:52])[CH3:51])[CH2:42][C@H:41]([NH:53][C:54](=[O:61])[C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)[C:40]1=[O:62])C1C=CC=CC=1>CO.[Pd]>[CH3:29][O:36][C:37](=[O:63])[CH2:38][N:39]1[C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=2[N:43]([C:50](=[O:52])[CH2:51][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:42][C@H:41]([NH:53][C:54](=[O:61])[C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)[C:40]1=[O:62]