Methylamine → N-(2-chloro-5-thiazolylmethyl)-N'-methyl-N"-nitroguanidine

HRID 613721노트

반응식

HRID 613721 반응식
CO[C:3](=[N:12][N+:13]([O-:15])=[O:14])[NH:4][CH2:5][C:6]1[S:10][C:9]([Cl:11])=[N:8][CH:7]=1.[CH3:16][NH2:17]>O>[Cl:11][C:9]1[S:10][C:6]([CH2:5][NH:4][C:3]([NH:17][CH3:16])=[N:12][N+:13]([O-:15])=[O:14])=[CH:7][N:8]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 136404632O-methyl-N-(2-chloro-5-thiazolylmethyl)-N'-nitroisourea

생성물 1

HCID 135779804N-(2-chloro-5-thiazolylmethyl)-N'-methyl-N"-nitroguanidine수율 92.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a suspension of O-methyl-N-(2-chloro-5-thiazolylmethyl)-N'-nitroisourea (1.00 g, 4.00 mmol) in water (10 ml) was added 40% aqueous solution of methylamine (0.77 g; 9.92 mmol) dropwise. The mixture was stirred at room temperature for 14 hours and the resulting crystals were collected by filtration, washed with water (10 ml), and dried. As a result, 0.92 g (92.0% yield) of 1-(2-chloro-5-thiazolylmethyl)-3-methyl-2-nitroguanidine was obtained.

후처리

  1. filtrationthe resulting crystals were collected by filtration
  2. washwashed with water (10 ml)
  3. customdried

출처 및 근거

ORD 기록
ord-85a0da82ae2548668d05048f3444d9bb
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008363

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