Sodium Chloride → O-methyl-N-(2-chloro-5-thiazolylmethyl)-N'-nitroisourea

Participants

Reaction Steps

To an aqueous solution (31 ml) of sodium chloride (6.1 g, 0.10 mol) and O-methyl-N-nitroisourea (1.5 g, 12.9 mmol) was added 5-(aminomethyl)-2-chlorothiazole hydrochloride (2.4 g, 12.5 mmol). The reaction mixture was adjusted to pH 7.0 with aqueous sodium hydroxide solution, and stirred at room temperature for 4 hours. The resulting white crystals were collected by filtration under reduced pressure, and washed with water. The washed crystals were dried under reduced pressure (80° C., 2 hours) to provide 1.92 g (60.8% yield) of O-methyl-N-(2-chloro-5-thiazolylmethyl)-N'-nitroisourea.

Provenance & Evidence