HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → 3-[2-(4-Hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)ethylamino]-N-[2-(2-phenyl-1-propoxy)ethyl]propanesulphonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Methyl 3-[2-(2-phenyl-1-propoxy)ethylaminosulphonyl]propanoate | HCID 18779042 | — |
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | 4-Hydroxy-7-(2-aminoethyl)-1,3-benzothiazol-2(3H)-one hydrochloride | HCID 60207553 | — |
| Product | 3-[2-(4-Hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)ethylamino]-N-[2-(2-phenyl-1-propoxy)ethyl]propanesulphonamide hydrochloride | HCID 18779050 | 10.1% |
Reaction Steps
The title compound (0.164 g) was prepared according to the procedure in example 5 part e using methyl 3-[2-(2-phenyl-1-propoxy)ethylaminosulphonyl]propanoate (1.01 g), diisobutylaluminiumhydride (1.5M in toluene, 3 ml), 7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrochloride (0.89 g) and sodium cyanoborohydride (0.19 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008365 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-9473385cd8f34196b6e62e956fd236ec |
| Source note | uspto-grants-1999_12 |