Phenylacetaldehyde → 4-(4-Acetamido-4-phenylpiperidino)-2-(3,4-dichlorophenyl)-N-phenethyl-N-[3,5-bis(trifluoromethyl)benzyl]butylamine

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Reaction Steps

Using a procedure similar to that described in Example 1, except replacing the (3,4-dichlorophenyl)butylamine and the 3,5-bis(trifluoromethyl)benzaldehyde used therein with 4-(4-acetamido-4-phenylpiperidino)-2-(3,4-dichlorophenyl)-N-[3,5-bis(trifluoromethyl)benzyl]butylamine and phenylacetaldehyde, respectively, the title compound was prepared; mp 55-57° C.; partial NMR (DMSO): 7.1-6.95 (broad m,11), 3.88 (d,1), 3.65 (d,1), 3.35(d,1), 3.15(d,1), 1.85 (s,3); MS: m/z=764(M+1,100%); TLC: Rf=0.44 (10:1 dichloromethane:methanol). Analysis for C40H41Cl2F6N3O: Calculated: C, 62.83; H, 5.40; N, 5.50; Found: C, 63.18; H, 5.71; N, 5.35.

Provenance & Evidence