Formic Acid → 7,7,8-Trimethyl-2,3,4,5,6,7-hexahydro-1H-3a,6-methanoazulene-3-carboxylic acid

HRID 613961Notes

Reaction equation

HRID 613961 reaction equation
[CH3:1][C:2]1([CH3:17])[C:9](=[CH2:10])[CH:8]2[CH2:11][CH2:12][CH:13]([C:14]([OH:16])=[O:15])[C:6]32[CH2:7][CH:3]1[CH2:4][CH2:5]3.C(O)=O.C(O)C>O>[CH3:10][C:9]1[C:2]([CH3:1])([CH3:17])[CH:3]2[CH2:7][C:6]3([CH2:5][CH2:4]2)[C:8]=1[CH2:11][CH2:12][CH:13]3[C:14]([OH:16])=[O:15]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 702EthanolHCID 859737,7-Dimethyl-8-methylideneoctahydro-1H-3a,6-methanoazulene-3-carboxylic acid

Product 1

HCID 277497,7,8-Trimethyl-2,3,4,5,6,7-hexahydro-1H-3a,6-methanoazulene-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

500 mg of vetivenic acid (see example 1) were treated with formic acid under the same conditions as those described in example 2. The pure compound was obtained after cristallization in a 1:1 mixture of ethanol and water.

Workup

  1. customThe pure compound was obtained after cristallization

Sources & evidence

ORD record
ord-9477e9e9e1094f07bf5ec526550a3d81
Source dataset
uspto-grants-1979_03
Patent number
US04142997

Reaction notes

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