反应详情

A reaction mixture consisting of 2.4 grams of 2,3-dihydro-6-methoxy-2-methyl-4-benzofuranamine, 10 cc of acetic anhydride and one drop of pyridine is heated to 130°-140° C. for 90 minutes. After cooling and evaporating the excess of acetic anhydride, the residue is distilled under reduced pressure yielding 2.4 grams (69 percent of theoretical) of the compound of the title. B.p./0.4 mmHg 160° C. The distillate which solidifies is crystallized from ethyl ether-petroleum ether. M.p. 56°-57° C.

1. temperatureis heated to 130°-140° C. for 90 minutes
2. temperatureAfter cooling
3. customevaporating the excess of acetic anhydride
4. distillationthe residue is distilled under reduced pressure
5. customyielding 2.4 grams (69 percent of theoretical) of the compound of the title
6. custom0.4 mmHg 160° C
7. customThe distillate which solidifies is crystallized from ethyl ether-petroleum ether