Benzyl chloroformate → HCID 54095129, compound

Participants

Reaction Steps

0.65 grams of phenylmethylchlorocarbonate are dripped at 5° C. into a stirred mixture containing 0.7 grams of 2,3-dihydro-6-methoxy-2-methyl-4-benzofuranamine hydrochloride, 5 cc of 2N NaOH and 10 cc of chloroform. When the addition is terminated vigorous stirring is continued for one hour at the same temperature and for two hours at room temperature. Then the organic phase is separated, washed with water, dried over Na2SO4 and concentrated to dryness. The obtained residue crystallized twice from ethyl ether-petroleum ether yields 0.9 grams (88 percent of theoretical) of (2,3-dihydro-6-methoxy-2-methyl-4-benzofuranyl)carbamic acid phenylmethyl ester which melts at 82°-83° C.

Provenance & Evidence