Dimethylformamide → HCID 21330001, compound

Participants

Reaction Steps

2.9 g 2,6-dimethylphenylisocyanide dichloride is added to a suspension of 5 g of 1-(1-aminoethyl)-3,4-dihydro-6,7-dimethoxyisoquinoline dihydrobromide in 100 ml dimethylformamide. 3.6 g of anhydrous potassium carbonate are then added. The suspension is stirred and warmed at 60° for 6 hours. The potassium carbonate is filtered off and washed with dimethylformamide. The washings and filtrate are concentrated in a vacuum, and the residue is chromatographed on silicagel using CHCl3 /CH3OH (95:5) as eluant to give the title compound as the free base; M.Pt. 234°-236°.

Provenance & Evidence