Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 614180Generated: November 1, 2026

Sodium Hydroxide → 3-(m-Tolyl)-4,5-Isothiazoledicarboxylic Acid

https://huagongshe.com/reaction/614180

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantDimethyl 3-(m-Tolyl)-4,5-IsothiazoledicarboxylateHCID 12437411—
SolventWaterHCID 962—
Product3-(m-Tolyl)-4,5-Isothiazoledicarboxylic AcidHCID 12437431—

Reaction Steps

Dimethyl 3-(m-tolyl)-4,5-isothiazoledicarboxylate (14.03 g, 0.0548 mol) was hydrolyzed in NaOH (10.96 g, 0.274 mol) and 50 ml H2O for 0.5 hours at reflux. Acidification with HCl, extraction with ether and recrystallization gave a light yellow solid, m.p. 166.5°-167° with decomposition.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04144047
Source datasetuspto-grants-1979_03
ORD IDord-3dc59a7c9a8540cf9ab02744def46396
Source noteuspto-grants-1979_03