Hydrochloric Acid → HCID 12437432, compound

Participants

Reaction Steps

Dimethyl 3-(m-chlorophenyl)-4,5-isothiazoledicarboxylate (14.51 g. 0.0504 mol) was hydrolyzed as given above with NaOH (10.08 g. 0.252 mol) and then acidified with HCl. The purified yellow solid had m.p. 185°-6° with decomposition (rapid heating of the sample produced normal decomposition in this temperature range; slow heating caused a color change to red and m.p. 217.5°-218.5° with decomposition. Infrared of material heated slowly to 190° showed that it was 3-(m-chlorophenyl)-4-isothiazolecarboxylic acid).

Provenance & Evidence