HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → 3-(3-Methylphenyl)-1,2-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | 3-(m-Tolyl)-4,5-Isothiazoledicarboxylic Acid | HCID 12437431 | — |
| Solvent | 1,2-Dichlorobenzene | HCID 7239 | — |
| Product | 3-(3-Methylphenyl)-1,2-thiazole-4-carboxylic acid | HCID 12437449 | 85.1% |
Reaction Steps
3-(m-Tolyl)-4,5-isothiazoledicarboxylic acid (7.98 g, 0.0303 mol) was heated in 25 ml of o-dichlorobenzene at vigorous reflux for 15 minutes and cooled. Hexane was added and the resultant precipitate was filtered off to yield 5.52 g (0.0258 mol, 83.1%) of a light pink solid, m.p. 144.5°-146°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04144047 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-d7c0910fa35a4a5bbe1a89b0a61867fd |
| Source note | uspto-grants-1979_03 |