HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 54338339, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | t-Butoxycarbonylglycine-2,4,5-Trichlorophenyl Ester | HCID 12799284 | — |
| Reactant | HCID 70603822 | HCID 70603822 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 54338339 | HCID 54338339 | — |
Reaction Steps
A solution of 6.1 parts glycyl-L-phenylalanine benzyl ester hydrochloride, 7.0 parts N-t-butoxycarbonylglycine 2,4,5-trichlorophenyl ester and 1.8 parts N-methylmorpholine in 150 parts methylene chloride is stirred overnight at room temperature. The solvents are then removed by evaporation under reduced pressure to yield the crude tripeptide. Purification by low pressure column chromatography affords pure N-t-butoxycarbonylglycylglycyl-L-phenylalanine benzyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04144228 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-51e5c6e633014b468d7fc6b39a0ba378 |
| Source note | uspto-grants-1979_03 |