1-(2-Hydroxyethyl)piperazine → HCID 12703405, compound

HRID 614212Notes

Reaction equation

HRID 614212 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8](Cl)=[N:7][C:6]=2[CH:16]=1.[OH:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30]>C1(C)C=CC=CC=1>[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8]([N:23]3[CH2:24][CH2:25][N:20]([CH2:19][CH2:18][OH:17])[CH2:21][CH2:22]3)=[N:7][C:6]=2[CH:16]=1

Participants

5

Reactant 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 444972Fumaric AcidHCID 21315986HCID 21315986, compound

Product 1

HCID 12703405HCID 12703405, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-Methyl-10-chloro-thieno[3,4-b][1,5]benzoxazepine (Example 7) is reacted with 20 ml. of N-(2-hydroxyethyl)-piperazine in 20 ml. of dry toluene as described in Example 1, giving the base compound which is further reacted with fumaric acid, giving the desired product as the fumarate salt, m.p. 178°-180° C.

Workup

  1. customgiving the base compound which

Sources & evidence

ORD record
ord-a696bce6bde149e49ac356758cffabf5
Source dataset
uspto-grants-1979_03
Patent number
US04144235

Reaction notes

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