1-(2-Hydroxyethyl)piperazine → HCID 12581868, compound

HRID 614215Notes

Reaction equation

HRID 614215 reaction equation
[OH:1]CCN1CCNCC1.C(O)(=O)/C=C/C(O)=O.[Cl:18][C:19]1[S:20][CH:21]=[C:22]2[C:28](N3CCN(CCO)CC3)=[N:27][C:26]3[CH:38]=[CH:39][CH:40]=[CH:41][C:25]=3[O:24][C:23]=12>C1(C)C=CC=CC=1>[Cl:18][C:19]1[S:20][CH:21]=[C:22]2[C:28](=[O:1])[NH:27][C:26]3[CH:38]=[CH:39][CH:40]=[CH:41][C:25]=3[O:24][C:23]=12

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 12703426HCID 12703426, compound

Product 1

HCID 12581868HCID 12581868, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 4.0 g. portion of the above product is reacted with 4.0 g. of phosphorus pentachloride in 103 ml. of dry toluene as described in Example 1, giving 3,10-dichloro-thieno[3,4-b][1,5]benzoxazepine which is further reacted with 25 ml. of N-hydroxyethylpiperazine and 25 ml. of dry toluene giving the base compound as a foam which is converted to 4-(3-chlorothieno[3,4-b][1,5]benzoxazepin-10-yl)-1-piperazine-ethanol fumarate, m.p. 144°-145° C.

Workup

  1. customis further reacted with 25 ml

Sources & evidence

ORD record
ord-b0fc7d67433242e49f57ed1bcbf4ab1e
Source dataset
uspto-grants-1979_03
Patent number
US04144235

Reaction notes

Loading…