HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-phenyl-2,5-dihydro-1H-pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 3-hydroxy-3-phenylpyrrolidine-1-carboxylate | HCID 66662569 | — |
| Product | 3-phenyl-2,5-dihydro-1H-pyrrole | HCID 3031531 | — |
Reaction Steps
A mixture of tert-butyl 3-hydroxy-3-phenylpyrrolidine-1-carboxylate (0.36 g, 0.0014 mol) and trifluoroacetic acid (2.0 mL, 0.026 mol) was stirred under nitrogen at room temp for 1 h. The volatile was removed under vacuum and evaporated with toluene twice. The residue was used in next step w/o further purification. LCMS: 146.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440958B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-65540827d1b44fe7a0ea409d9c544733 |
| Source note | uspto-grants-2016_09 |