反应详情

To a solution of 7 g of rifamycin S in 200 ml of methanol a mixture was added containing 1.8 g of the hydrochloride of cysteine methyl ester and 1.53 g of triethylamine. The mixture was refluxed for 20 minutes and then 20 ml of a buffer pH 4.6 containing 2.2 g of dichlorodicyano-p-quinone was added. The mixture was allowed to stand at room temperature for 15 hours and then was treated as described in Example 1 to obtain the rifamycin P. Yield 2.8 g of the title product.

1. temperatureThe mixture was refluxed for 20 minutes
2. additionwas added
3. additionwas treated